Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Jose María Ruiz-Moreno
Spain
Research Article
Role of Systemic Anti-Tumor Necrosis Factor Alpha Treatment in the Reduction of Proliferative Vitreoretinopathy
Author(s): Laura Jimeno, Maria Rosa Sanabria, Ivan Fernandez-Bueno, Lior Lipski, Anat Loewenestein, Amandio Rocha-Sousa, Cristina Ferreira-Sousa, Alfredo Adan, Marina Mesquida, Salvatore Di Lauro, Jose María Ruiz-Moreno, Ignacio Flores, Marta Fernandez, Alfredo Garcia Layana and Jose Carlos PastorLaura Jimeno, Maria Rosa Sanabria, Ivan Fernandez-Bueno, Lior Lipski, Anat Loewenestein, Amandio Rocha-Sousa, Cristina Ferreira-Sousa, Alfredo Adan, Marina Mesquida, Salvatore Di Lauro, Jose María Ruiz-Moreno, Ignacio Flores, Marta Fernandez, Alfredo Garcia Layana and Jose Carlos Pastor
Objective: Proliferative vitreoretinopathy (PVR) is still one of the most serious complications of rhegmatogenous retinal detachment (RRD) because there is no effective treatment or prophylaxis. Tumor necrosis factor α (TNFα) has been implicated in the development of PVR. Thus, the blockade of this factor could reduce or prevent the onset of PVR. However, systemic treatment with anti-TNFα has some risks and side effects, and the use of these drugs in this situation is not yet justified. Therefore we sought an indirect approach to determine if systemic anti-TNFα provided any protection against the development of PVR after RRD surgery. We attempted to estimate the rate of RRD and PVR in patients who were treated systemically with anti-TNFα drugs because of autoimmune diseases and who also had surgically-treated RRD.
Methods: .. Read More»
DOI:
10.4172/2155-9570.1000464
