Journal of Drug Metabolism & Toxicology
Open Access

Jiri Kriz

Publications

• Case Report
  Serum Creatinine Levels May Not Necessarily Reflect a True Renal Function to Adjust Amikacin Dose in Paraplegic Patient: A Case Report and Literature Review
  Author(s): Hundie Tesfaye, Blanka Jedlickova, Richard Prusa, Renata Hakova and Jiri KrizHundie Tesfaye, Blanka Jedlickova, Richard Prusa, Renata Hakova and Jiri Kriz
  
  To estimate glomerular filtration rate as an indicator of kidney function, clearance of endogenous creatinine is usually used despite its unreliability due to influence of several factors including age, gender, muscle mass and interferences within methods. Although there is emergence of better markers like serum cystatin-C, creatinine clearance continues to be used routinely as a marker of renal function to date. In the present case study we describe only slightly elevation of serum creatinine associated with high serum drug concentration 27 mg/L “trough” and 41 mg/L “peak”, respectively in a paraplegic patient treated with initially reduced dose (500 mg/day) of an aminoglycoside antibacterial drug (amikacin). The relatively little increment of serum creatinine in this case might be related to underlying pathology resulting in low production.. View More»
  DOI: 10.4172/2157-7609.1000209

  Abstract PDF

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