Journal of Drug Metabolism & Toxicology
Open Access

Jayarama Reddy Venugopal

Publications

• Research Article
  Controlled Release of Dexamethasone in PCL/Silk Fibroin/Ascorbic Acid Nanoparticles for the Initiation of Adipose Derived Stem Cells into Osteogenesis
  Author(s): Chinnasamy Gandhimathi, Neo Xuan Hao Edwin, Praveena Jayaraman, Jayarama Reddy Venugopal, Seeram Ramakrishna and Srinivasan Dinesh KumarChinnasamy Gandhimathi, Neo Xuan Hao Edwin, Praveena Jayaraman, Jayarama Reddy Venugopal, Seeram Ramakrishna and Srinivasan Dinesh Kumar
  
  Mimicking hybrid extracellular matrix is one of the major challenges in bone tissue engineering. Biocomposite micro/nanoparticle of polycaprolactone (PCL), silk fibroin (SF), ascorbic acid (AA) and dexamethasone (DM) were fabricated by the electrospraying methods in order to generate an improved osteogenic environment for the proliferation and differentiation of adipose derived stem cells (ADSCs) into osteogenesis. Fabricated electrosprayed micro/nanoparticle was characterized for particle morphology, hydrophilicity, porosity and FTIR analysis for bone tissue regeneration. FESEM micrographs of the nanoparticles revealed porous, fibreless, uniform particles with particle diameter in the range of 720 ± 1.8 nm - 3.5 ± 4.2 μm. The drug release profile indicates that the sustained release of dexamethasone up to 10 days and degradation of nanoparticles around 13-20% after 6.. View More»
  DOI: 10.4172/2157-7609.1000177

  Abstract PDF

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