Autism-Open Access
Open Access

James W Howell

Publications

• Review Article
  Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders
  Author(s): Detlef H Heck and James W HowellDetlef H Heck and James W Howell
  
  This review reveals possible explanations for the link between cerebellar neuropathology and cognitive disorders, with an emphasis on autism and schizophrenia. There is a growing body of evidence showing these two conditions to be related. The loss of Purkinje cells, the principal neurons of the cerebellar cortex, is one of the most consistent neuropathologies found in autistic brains. Cerebellar neurophathologies are a common finding in schizophrenia, as well. The cerebellum has long been considered a pure motor structure, and it’s involvement in cognitive disorders remained obscure. The cognitive deficits typically associated with autism and schizophrenia strongly implicate prefrontal cerebral cortical pathology. We review recent findings, which provide new insights into suggest possible neuronal mechanisms through which the cerebellum might interact with the prefrontal cortex.. View More»
  DOI: 10.4172/2165-7890.S4-001

  Abstract PDF

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