Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Ismail Celik
Science Faculty, Biology Department,
65080 Van
Turkey
Research Article
Effects of Subacute and Subchronic Treatment of Synthetic Plant Growth Regulators on Liver Damage Serum Biomarkers Tissue Antioxidant Defense Systems and Lipid Peroxidation in Rats
Author(s): Necati Ozok and Ismail CelikNecati Ozok and Ismail Celik
The present study was aimed to investigate the effects of some synthetic plant growth regulators; ß-Naphthoxy acetic acid (ß-NOA) and 4-Chlorophenoxy acetic acid (4-CPA) at 10 and 20 ppm dosages on liver damage, antioxidant defense system and lipid peroxidation in rats. Rats were divided into 12 groups as control, ß-NOA and 4-CPA at 10 and 20 ppm dosages application groups. Serum marker enzymes and biochemical parameters were selected as biomarkers for liver damage. Antioxidant defense systems as SOD, GR, CAT, GSH-Px, GST and G6PD enzyme activities and GSH and MDA contents were determined in tissues as the indicators of oxidative stress. At the end of experiments, the statistically significant changes were observed in the levels of TPRO, TALB, TCHOL, TBIL, AST, ALT and LDH as liver damage serum biomarkers in rats exposed to 10 and 20 ppm of ß-N.. View More»
DOI:
10.4172/2157-7609.1000124