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Open Access
ISSN: 2165-7890
ISSN: 2165-7890
Iman HM Bakr
Egypt
Research Article
Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats
Author(s): Hassan IH El Sayyad, Iman HM Bakr, Ahmed A El Mansi, Ali H amin, Mohamed E El Beeh and Adel MA AsiriHassan IH El Sayyad, Iman HM Bakr, Ahmed A El Mansi, Ali H amin, Mohamed E El Beeh and Adel MA Asiri
Diabetes and hypercholesterolemia are dyslipidemic diseases and have certain role in brain dysfunction, but little of works are concerning with it. In the present study we used eighty male Wistar rats weighing approximately 100 ±15 gram. The animals were arranged into 8 groups; Control (C), fish oil-treatment, hypercholesterolemic group (H), hypercholesterolemic & fish oil-treatment (HF), diabetic- group (D), diabetic and fish oil-treatment (DF), combined hypercholesterolemic and diabetic group (HD) and combined hypercholesterolemic and diabetic group and fish-oil-treatment (HDF). Diabetes was induced by streptozotocin (40mg/kg single dose in citrate buffer pH4.6). Hypercholesterolemia was carried out by feeding rats on diet containin3% cholesterol. Fish oil (Menhaden, Sigmaaldrich, highest purity) was supplemented orally every other day at 100mg/kg body weight. Treatment was.. View More»
DOI:
10.4172/2165-7890.1000148