Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Ichiro Ieiri
Graduate School of Pharmaceutical Sciences,
Fukuoka
Japan
Short Communication
Effect of Curcumin on Sulfasalazine Pharmacokinetics in Healthy Volunteers
Author(s): Tomoko Tokumoto, Takeshi Hirota, Keisuke Gotanda, Miyuki Kimura, Shin Irie, Masato Fukae and Ichiro IeiriTomoko Tokumoto, Takeshi Hirota, Keisuke Gotanda, Miyuki Kimura, Shin Irie, Masato Fukae and Ichiro Ieiri
Curcumin, a commonly used spice, is a naturally occurring polyphenol. It has been reported that curcumin inhibited the transport activity of breast cancer resistance protein (BCRP/ABCG2) in animal studies, and curcumin caused significantly increased plasma concentrations of sulfasalazine (SASP), an in vivo probe for BCRP function in human. In this study, we assessed the influence of prior administration of curcumin on the pharmacokinetics of SASP. An open-label, single-arm and two-phase study was conducted in 34 healthy participants. A single dose of SASP (2,000 mg) was administered orally after overnight fast (phase 1). After seven days washout period, a single oral dose of curcumin (2,000 mg) was administered, and then, 4 days to 5 days after administration of curcumin, 2,000 mg of SASP was administered orally again (phase 2). Plasma concentrations of SASP were assayed by highperforman.. View More»
DOI:
10.4172/2157-7609.1000206