Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
ISSN: 2157-7609
Hassan IH El-Sayyad
Egypt
Research Article
Abnormal Retinal Structure and Function of Mother Wistar Rats Supplemented Aspartame, Glutamate and Galactose
Author(s): Hassan IH El-Sayyad, Amora M Abou-El-Naga, Soad A Khalifa, Eman A El-Shahari and Hamed AN JalaHassan IH El-Sayyad, Amora M Abou-El-Naga, Soad A Khalifa, Eman A El-Shahari and Hamed AN Jala
Three dietary supplements are investigated in the present study. Aspartame is a low calorie sweetener utilized instead of sugar for diabetic patients. Monosodium Glutamate (MSG) is used in varieties of food stuffs to enhance food flavor. Meanwhile galactose is presents in many of food items such as milk, dairy products, fruits and vegetables and overloads enhanced aging like process and altered body function. The present work aimed to illustrate the effect of dietary supplements of aspartame, glutamate and galactose in retina of mother Wistar rats. Virgin Wistar rats were mated with fertile male and zero date of pregnancy was determined. Pregnant rats were orally administered aspartame (100 mg/kg), monosodium glutamate (500 mg/kg) and galactose (1 g/kg body weight) from 6th day of gestation until parturition and 21 days post-partum. Four main groups of pregnant rats were used; control, a.. View More»
DOI:
10.4172/2157-7609.1000219