Journal of Leukemia

Journal of Leukemia
Open Access

ISSN: 2329-6917

+44 1300 500008

Hai-tao Sun

Hai-tao Sun
Zhujiang Hospital,
Guangzhou 510282
China

Publications
  • Research Article
    Human Amniotic Mesenchymal Stem Cells Exhibit Similar Immunosuppressive Ability with Bone Marrow Mesenchymal Stem Cells and Possess a Higher Proliferation Activity and Clearer Stem Cell Properties in vitro
    Author(s): Ya Gao,Ying Xu, Jie Song, Jia-qiong Hong, Wei-bin Zhuo, Chun-yan Yang, Yu Zhang, Zhi-ping Fan, Yan-wu Guo, Chun-yan Yue, Hai-tao Sun andBao-hong PingYa Gao,Ying Xu, Jie Song, Jia-qiong Hong, Wei-bin Zhuo, Chun-yan Yang, Yu Zhang, Zhi-ping Fan, Yan-wu Guo, Chun-yan Yue, Hai-tao Sun andBao-hong Ping

    Objectives: Human bone marrow mesenchymal stem cells (hBMSCs) have been used for the prevention and treatment of acute graft-versus-host disease (aGVHD) in post-hematopoietic stem cell transplant patients. In this study, we compared the biological characteristics and immunosuppressive activity of human amniotic mesenchymal stem cells (hAMSCs) and hBMSCs to provide experimental evidence for the potential use of hAMSCs for treating aGVHD, thus solving the problem of insufficient hBMSCs sources. Methods: HAMSCs were isolated by enzymatic digestion. hBMSCs were isolated using Ficoll-Hypaque density gradients. The biological characteristics of both stem cell types were compared by morphological analysis, analysis of cell growth, cell cycle profiling, immunophenotyping, and immunofluorescence assays. An in vitro co-culture of MSCs and peripheral blood mononuclear cells (PBMCs) was performed.. View More»
    DOI: 10.4172/2329-6917.1000234

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