Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Research Article
Formulation and Evaluation of Betamethasone Sodium Phosphate Loaded Nanoparticles for Ophthalmic Delivery
Author(s): Mohamed Ali Attia Shafie and Hadeel Hamdy Mohammed FayekMohamed Ali Attia Shafie and Hadeel Hamdy Mohammed Fayek
Betamethasone sodium phosphate is a potent glucocorticoid with anti-inflammatory activity and can be used in treatment of macular edema. The aim of this work is to formulate and investigate mucoadhesive chitosan-sodium alginate nanoparticles as new vehicle for the prolonged topical ophthalmic delivery of betamethasone sodium phosphate. Ionotropic gelation method was used to produce betamethasone loaded chitosan alginate nanoreservoir system. The effect of changing different formulation parameters (pH of chitosan solution, sodium alginate concentration, calcium chloride concentration, chitosan concentration, drug concentration and the addition of tween 80) on the physicochemical properties and in vitro release of the drug loaded nanoparticles was studied. The mean particle size ranged from 16.8 to 692 nm and the zeta potential generally ranged from +18.49 to +29.83 mV dependin.. View More»
DOI:
10.4172/2155-9570.1000273