Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Grazyna Adamus
Ocular Immunology Laboratory L467AM,
3181 SW Sam Jackson Pk Rd Portland, OR 97239
Tanzania
Research Article
Significance of Anti-retinal Autoantibodies in Cancer-associated Retinopathy with Gynecological Cancers
Author(s): Grazyna Adamus, Dongseak Choi, Anitha Raghunath and Jade SchiffmanGrazyna Adamus, Dongseak Choi, Anitha Raghunath and Jade Schiffman
Background: The presence of autoantibodies (AAbs) is the primary serological indicator of autoimmunity. Cancerassociated retinopathy (CAR) is associated with AAbs and different types of cancer. The goal of the study was to examine the profile of serum autoantibodies in women with gynecological cancers with and without paraneoplastic visual manifestation.
Methods: Retrospective studies of a cohort of 46 women with symptoms of CAR and gynecological tumors, including endometrial, cervical, ovarian, and fallopian tubes, 111 women with similar tumors without symptoms of CAR, and 60 age-matched healthy controls. Presence of serum AAbs and the identity of targeted antigens were performed by western blotting and their significance was evaluated using an Fisher’s exact test.
Results: The patients with gynecological CAR ha.. View More»
DOI:
10.4172/2155-9570.1000307