Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Gopalan N
India
Research Article
Pyridostigmine Bromide and Potassium Iodate: Subacute Oral Toxicity and Stability
Author(s): Papiya Bigoniya, Anil Kumar Singh, Dharmesh Bigoniya and Gopalan NPapiya Bigoniya, Anil Kumar Singh, Dharmesh Bigoniya and Gopalan N
Subacute toxicity of pyridostigmine bromide (PB) and potassium iodate (PI) tablets upon forty five days administration were assessed by changes in body weight, hematology, serum biochemical parameters and histopathology of rat liver and kidney. LD50 of PB was estimated to be 66.9 mg/kg. At dose of 45 mg/kg/day showed decrease in body weight and liver weight with cytoplasmic acidophilic bodies and vesicular steatosis signifying hepatocellular injury. Kidney tissue developed neutrophil polymorph infiltration with inflammatory glomerulonephritis, protein casts and glomerulosclerosis. Serum SGOT, SGPT, ALP and lipid profile were elevated. The oral LD50 of PI was found to be 944.6 mg/kg. PI at 150 mg/kg dose showed anorexia and body weight loss. Serum SGOT, ALP, cholesterol and triglyceride level were elevated at 85 and 150 mg/kg dose and focal area of tubular injury and inflammatory cell inf.. View More»
DOI:
10.4172/2157-7609.1000145