Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Ghareb M. Soliman
Egypt
Research Article
Development and in vitro/in vivo Evaluation of Liposomal Gels for the Sustained Ocular Delivery of Latanoprost
Author(s): Dina Fathalla, Ghareb M. Soliman and Ehab A. FouadDina Fathalla, Ghareb M. Soliman and Ehab A. Fouad
Objective: Conventional eye drops commonly used in the treatment of glaucoma suffer from short residence time, which results in frequent administration and poor patient compliance. The objective of this work was to develop a liposome-based delivery system for the sustained ocular delivery of latanoprost, a prostaglandin analog commonly used in the management of glaucoma.
Methods: Latanoprost was incorporated into different liposomes that were evaluated using variety of techniques. Selected liposomes were incorporated into different gels and their viscosity and drug release kinetics were evaluated. Optimal liposomal gels were evaluated in vivo in rabbits’ eyes for their irritation potential and ability to reduce intraocular pressure.
Results: Fourier transform infrared and differential scanning calorimetry studies c.. View More»
DOI:
10.4172/2155-9570.1000390