Journal of Drug Metabolism & Toxicology
Open Access

Gaedigk

Biography

Gaedigk is the Manager of the Pharmacogenetics Core Laboratory in the Division of Clinical
Pharmacology and Medical Toxicology at Children’s Mercy Hospitals and Clinics in Kansas
City, MO. She holds faculty appointments as Associate Professor of Pediatrics and
Pharmacology at the University of Missouri-Kansas City as well as an adjunct faculty position in
the Department of Clinical Laboratory Sciences, at the University of Kansas Medical Center.
Dr Gaedigk is a dedicated teacher and has worked with numerous fellows, physician scientists,
summer students and visiting professors since she joined Children’s Mercy Hospital in August of
1996. She is also actively involved in a number of professional societies including the American
Society of Pharmacology and Experimental Therapeutics were she is a member of the Executive
Committee of the Division of Integrative Systems, Translational and Clinical Pharmacology and
the American Society of Clinical Pharmacology where she has served as Section Chair and is
currently member of the Program Committee. Dr Gaedigk has published over 75 articles in peerreviewed
journals, reviewed for over 20 journals and is a member of the Editorial Board of the
European Journal of Clinical Pharmacology. Her work has been well supported by intramural
funding and she has served as an investigator on NIH-funded projects.
Dr Gaedigk received a Masters of Science and a Doctor of Natural Sciences degree from the
University of Stuttgart, Germany. After graduation, she completed a postdoctoral fellowship in
the Department of Clinical Pharmacology at the Hospital for Sick Children in Toronto, Canada
and held a position as Research Associate. Her research interests focus around the
pharmacogenetics of enzymes involved in drug metabolism and disposition, drug transporters
and receptors. Ongoing studies investigate the relationship between phenotype and genotype,
inter-individual variation in enzyme activity and variations observed among populations of
different ethnic backgrounds. She is also instrumental in ongoing investigations studying the
expression of those genes during human development and childhood and has a long-standing
interest in the role of drug-metabolizing enzymes in adverse drug events 

Research Interest

 Pediatrics, Pharmacology, Clinical Pharmacology and Medical Toxicology

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