Current Synthetic and Systems Biology

Current Synthetic and Systems Biology
Open Access

ISSN: 2332-0737


Fabio Kendi Tamaki

Fabio Kendi Tamaki

United Kingdom

  • Editorial
    Cyclic Peptides as Modulators of Protein-Protein Interactions
    Author(s): Fabio Kendi Tamaki and Helder I NakayaFabio Kendi Tamaki and Helder I Nakaya

    Biological processes operate through intricate networks comprised of a myriad of interacting molecules. Protein-protein interactions (PPIs) permeate these networks and are able to transmit and integrate the signalling pathways inside the cells in response to physiological and non-physiological conditions (including cellular pathologies as cancer). To assess the role of such interactions, peptidic compounds have been developed aiming to modulate intracellular PPIs. For instance, structural studies demonstrated in humans and roundworms that the α-helical MAML1 polypeptide binds to a groove formed by the PPI between ICN1 and CLS proteins. The ICN1-CLS-MAML ternary complex plays a key role on NOTCH1 signalling pathway by recruiting the transcription machinery and leading to the transcription of oncogenic NOTCH1 target genes. The group of Dr. James E. Bradner (Harvard Medical School).. Read More»
    DOI: 10.4172/2332-0737.1000e118

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