Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Elsayed Mohammed Tayee
Egypt
Research Article
Effect of CB1-Antagonist (AM251) on Metabolic Syndrome (Prophylactic and Therapeutic)
Author(s): Ahmed Mohammed Taha, Elsayed Mohammed Tayee, Dalia Ali Gaber, Deaa Fekri Morsi and Abdelbaset Taher AbdelhalimAhmed Mohammed Taha, Elsayed Mohammed Tayee, Dalia Ali Gaber, Deaa Fekri Morsi and Abdelbaset Taher Abdelhalim
The present study was designed to investigate the possible prophylactic and therapeutic effect of cannabinoid receptors type1 (CB1) antagonist (AM251) on fructose-induced metabolic syndrome in rats, through administration of high fructose diet for 12 weeks. Prophylactic treatment by CB1-antagonist (AM251) significantly returned triglyceride, inflammatory, oxidative stress parameters and liver enzymes to the normal values while it significantly improved blood pressure, glucose, insulin, and IR and lipid profile but not significantly returned to the normal values. Interestingly, it significantly decreased body weight to values less than corresponding normal group. Histopathological findings confirmed that CB1-antagonist (AM251) in both prophylactic and therapeutic group improved histopathological changes of the liver and aorta induced by high fructose (60%) diet, with .. View More»
DOI:
10.4172/2157-7609.1000236