Journal of Clinical and Experimental Ophthalmology
Open Access

Domenico Mastrangelo

Publications

• Research Article
  Megadoses of Ascorbate as a New Chemotherapeutic Approach in Uveal Melanoma: A Preliminary In Vitro Investigation
  Author(s): Domenico Mastrangelo, Lauretta Massai, Klara Valyi-Nagy, Michela Muscettola, Margherita Aglianò, Leda Lodi, Francesco Di Pisa and Giovanni GrassoDomenico Mastrangelo, Lauretta Massai, Klara Valyi-Nagy, Michela Muscettola, Margherita Aglianò, Leda Lodi, Francesco Di Pisa and Giovanni Grasso
  
  Background: Despite the more recent advances, there is still no effective systemic therapy for Uveal Melanoma (UM). However, a better understanding of the role of oxidative stress in cancer, has more recently led to a completely new approach to the systemic therapy of cancer, and modulators of the oxidative balance, such as sodium ascorbate (ASC) or arsenic trioxide (ATO), have already entered advanced phases of preclinical and clinical development. Since high doses of ASC have already demonstrated a strong cytotoxic effect on different human cancer cell lines, we have undertaken the present investigation in order to test the sensitivity of OCM1 and C918 uveal melanoma (UM) cell lines to high doses of ASC, in vitro, as compared to ATO, a pro-oxidant drug which has already undergone extensive in vitro and pre-clinical investigation in UM. .. View More»
  DOI: 10.4172/2155-9570.1000315

  Abstract PDF

Relevant Topics