Journal of Leukemia
Open Access
ISSN: 2329-6917
ISSN: 2329-6917
Dewi K Paramita
Indonesia
Research Article
HES-1 and CEBPA mRNA in Chronic and Late Phase (accelerated and blast crisis) of Chronic Myeloid Leukemia (CML) Patients
Author(s): Selvi Rahmawati, Sri Fatmawati, Stefanus Purwanto, Eugeu Yasmin, Susan Simanjaya, Susanna H Hutajulu and Dewi K ParamitaSelvi Rahmawati, Sri Fatmawati, Stefanus Purwanto, Eugeu Yasmin, Susan Simanjaya, Susanna H Hutajulu and Dewi K Paramita
Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder of hematopoietic , characterized by Philadelphia chromosome containing BCR-ABL fusion gene. The gene encodes protein with constitutive tyrosine kinase activity result in myeloid proliferation and leads to form an early phase of CML called chronic phase. Unsuccessful treatment will lead to progression of the disease into late phase (accelerated and blast crisis). The mechanisms involving disease progression are still poorly understood. It is assumed that additional genetic event involves in differentiation blocking of myeloid progenitor cells, such as Hes-1 overexpression and CEBPA down regulation. However, study on the expression of these genes in CML patient’s samples is still limited. This study aims to measure Hes-1 and CEBPA mRNA in chronic and late phase of CML patients. The peripheral blood mRNA level of Hes-1.. View More»
DOI:
10.4172/2329-6917.1000225