Journal of Clinical and Experimental Ophthalmology

Journal of Clinical and Experimental Ophthalmology
Open Access

ISSN: 2155-9570

De-Quan Li

De-Quan Li

Associate Professor 

Biography

Dr. De-Quan Li is an experienced cellular and molecular biologist in medicine and life science research. After obtained the M.D. and Ph.D. from Shanghai Jiao Tong University, School of Medicine, he has been well trained in the modern biomedical technology during 2 terms of postdoctoral training periods in Departments of Endocrinology (1989-1991) and Ophthalmology (1992-1994) in University of Miami, Florida. Since 1992, He has dedicated to ocular surface research with major focuses on dry eye pathogenesis and corneal epithelial stem cells for 21 years, including 9 years in Bascom Palmer Eye Institute, University of Miami, and 12 years in Baylor College of Medicine as a faculty and a standing committee member. He has published 8 book chapters and 120 articles in top peer-reviewed scientific journals. He is an active reviewer member for 35 scientific journals and 11 national institutions with scientific foundations from 9 countries worldwide.

Research Interest
  • Research interest is focused on the studies of cell biology and molecular biology of ocular surface and tear, 
  • with major interest on: (1) experimental mouse dry eye model, 
  • (2) hyperosmolarity stress induces MMPs and inflammatory cytokines in human corneal epithelial cells via a JNK pathway, 
  • (3) corneal limbal stem cell cultures, 
  • (4) identification of corneal epithelial stem cells, 
  • (5) isolation of corneal epithelial stem cells from corneal limbal tissue and cultures, 
  • (6) corneal tissue bioengineering and gene therapy, 
  • (7) corneal immune defensive privilege and stem cells, 
  • (8) molecular regulation of innate and adaptive immune responses by corneal and conjunctival epithelial cells, 
  • (9) Th17 pathway on ocular surface and dry eye, 
  • (10) TSLP as a biomarker for ocular surface allergic inflammation, 
  • (11) toll-like receptors (TLRs) in mucosal immunity, 
  • (12) Pollen induces allergic inflammation via TLR4-dependent signaling pathways.

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