Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
David S Boyer
Tanzania
Research Article
Tears of the Retinal Pigment Epithelium during Aflibercept Therapy: PED and Treatment Characteristics
Author(s): Michelle V Carle, Thomas G Chu, Pouya Dayani, Homayoun Tabandeh, Natalie Truong and David S BoyerMichelle V Carle, Thomas G Chu, Pouya Dayani, Homayoun Tabandeh, Natalie Truong and David S Boyer
Background: Tears of the Retinal Pigment Epithelium (RPE) are associated with Age-Related Macular Degeneration (AMD) in the setting of a pigment epithelial detachment (PED). Methods: Chart review of patients treated with intravitreal (IV) Aflibercept for neovascular AMD (nvAMD). Clinical course and OCT images were analyzed to compare characteristics for patients who experienced RPE tears during treatment of symptomatic PED with IV Aflibercept. Results: 8 eyes of 8 patients were included in the study. All cases were being treated for nvAMD with IV aflibercept. The average maximal height of PED was 475 μm (172-874 μm), and the mean linear diameter was 3426 μm, (1004-5185 μm). All eyes had associated subretinal fluid; 4 had RPE folds and irregularities, and one had subretinal hemorrhage. Four eyes experien.. View More»
DOI:
10.4172/2155-9570.1000373