Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Research Article
Intravitreal Administration of Lysine-Acetylsalicylate Could be an Effective Approach to Preserve Retinal Vessels and to Inhibit Leukostasis in Experimental Diabetic Retinopathy
Author(s): Cristian Fernández-Martínez, José J. Martínez-Toldos, José M. Ruiz-Moreno, Elena Caminos and Ana Murcia-Lopez
Cristian Fernández-Martínez, José J. Martínez-Toldos, José M. Ruiz-Moreno, Elena Caminos and Ana Murcia-Lopez
Leukostasis and the loss of retinal capillaries associated with inflammation play a central role in the development of diabetic retinopathy. The oral administration of acetylsalicylic acid (ASA) at high doses has been associated with therapeutic benefits in experimental diabetic retinopathy. Although, its utility in humans remains controversial. We explore the ability of intravitreal injection of lysine acetylsalicylate to preserve retinal vessels and to inhibit the presence of leukocytes in the retinal ganglion cell (GCL) layer and the outer plexiform layer (OPL) using an experimental model of diabetic retinopathy induced with streptozotocin.
The diabetic animals were assigned to two groups, one of them received 2 doses of intravitreal lysine acetylsalicylate (lysine-group) while the other group received 2 intravitreal injections of saline (control-group). The two injections i.. View More»
DOI:
10.4172/2155-9570.1000709