Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Cosimo Mazzotta
Chirurgiche e Neuroscienze, U.O.C Oculistica Policlinico Santa Maria delle Scotte,
Viale Bracci 8, 53100 Siena
Italy
Research Article
Qualitative Investigation of Corneal Changes after Accelerated Corneal Collagen Cross-linking (A-CXL) by In vivo Confocal Microscopy and Corneal OCT
Author(s): Anna Lucia Paradiso, Cosimo Mazzotta, Stefano Baiocchi, Aldo Caporossi and Aldo CaporossiAnna Lucia Paradiso, Cosimo Mazzotta, Stefano Baiocchi, Aldo Caporossi and Aldo Caporossi
Purpose: To assess qualitative micro-morphological corneal changes by confocal microscopy and corneal OCT after accelerated corneal crosslinking (A-CXL) in keratoconic patients.
Study design: Prospective non-randomized pilot study.
Methods: 20 eyes of 20 patients, aged between 13 and 26 years (mean 22.6 years) underwent A-CXL by the KXL UV-A source (Avedro Inc. Waltham MA, USA). Patients were divided into 4 groups according to different riboflavin solutions and UV A powers.15 patients underwent epithelium-off A-CXL: 5 (Group 1) by riboflavin 0.1% plus dextran 20% at 12 mW/cm2 for 10 min; 5 (Group 2) at 30 mW/cm2 for 4 min; 5 (Group 3) by dextran-free riboflavin 0.1% plus HPMC at 30 mW/cm2 for 4 min and 5 (Group 4) by riboflavin 0.25% plus EDTA, BAK, TRIS epithelium-on A-CXL for 2 min and 40 sec. Micro-morphological ana.. View More»
DOI:
10.4172/2155-9570.1000313