Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Carlota Saldanha
Instituto de Bioquímica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Edifício Egas Moniz,
Av. Prof. Egas Moniz, 1649-028 Lisboa
Portugal
Research Article
Timolol Modulates Erythrocyte Nitric Oxide Bioavailability
Author(s): Carlota Saldanha, Pedro Teixeira, Santos-Freitas T and Patrícia NapoleãoCarlota Saldanha, Pedro Teixeira, Santos-Freitas T and Patrícia Napoleão
Changes of oxygen partial pressure in tissues are sensed by the erythrocytes that with the efflux or with the maintenance of nitric oxide that contains promote vasodilation or vasoconstriction. Binding of acetylcholine with the acetylcholinesterase of the erythrocyte membrane originates a signal transduction mechanism that involves both the Gi protein as well as band 3 protein what stimulates nitric oxide efflux. The bioavailability of nitric oxide in presence of velnacrine maleate an inhibitor of acetylcholinesterase is preserved what means that there are no changes in the nitric oxide efflux. Timolol maleate is an inhibitor of acetylcholinesterase.The aim of this study was to assess the role of the timolol maleate in the erythrocyte in respect to bioavailability on nitric oxide and compare it with effect resulting of the presence of acetylcholine. Venous blood samples were col.. View More»
DOI:
10.4172/2155-9570.1000285