Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609


Brandon Croft

Brandon Croft


  • Review Article
    Ubiquitin-Proteasome System in Neurodegenerative Disorders
    Author(s): Geeta Rao, Brandon Croft, Chengwen Teng and Vibhudutta AwasthiGeeta Rao, Brandon Croft, Chengwen Teng and Vibhudutta Awasthi

    Cellular proteostasis is a highly dynamic process and is primarily carried out by the degradation tools of ubiquitinproteasome system (UPS). Abnormalities in UPS function result in the accumulation of damaged or misfolded proteins which can form intra- and extracellular aggregated proteinaceous deposits leading to cellular dysfunction and/or death. Deposition of abnormal protein aggregates and the cellular inability to clear them have been implicated in the pathogenesis of a number of neurodegenerative disorders such as Alzheimer’s and Parkinson’s. Contrary to the upregulation of proteasome function in oncogenesis and the use of proteasome inhibition as a therapeutic strategy, activation of proteasome function would serve therapeutic objectives of treatment of neurodegenerative diseases. This review describes the current understanding of the role of the proteasome in neuro.. View More»
    DOI: 10.4172/2157-7609.1000187

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