Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Beverly D Lyn-Cook
Division of Biochemical Toxicology, FDA/National Center for Toxicological Research,
HFT-100,, Jefferson, Arkansas
Tanzania
Research Article
Epigenome-Wide Association (DNA Methylation) Study of Sex Differences in Normal Human Kidney
Author(s): Stancy Joseph, Nysia I George, Bridgett Green-Knox, Tamara Nicolson, George Hammons, Beverly Word, Shiew-Mei Huang and Beverly D Lyn-CookStancy Joseph, Nysia I George, Bridgett Green-Knox, Tamara Nicolson, George Hammons, Beverly Word, Shiew-Mei Huang and Beverly D Lyn-Cook
Studies have identified epigenetic sex differences in several human tissues and have implicated epigenetic factors in the regulation of tissue-specific expression. Studies have also shown that women and men respond differently to various drugs, thereby influencing the pharmacokinetics, pharmacodynamics, adverse reactions, efficacy, and safety of a drug. Using Illumina Human Methylation450 BeadChip kit, we investigated the influence of sex on DNA methylation patterns in normal human kidneys (16 females and 15 males). We then related the methylome to mRNA expression levels in kidney structure/function and Drug Metabolizing Enzyme and Transporter (DMET) genes (32 females and 59 males). Our findings indicate that 429 methylated sites on autosomal chromosomes had significant sex-specific differences in the normal human kidney. Methylated sites in/near regions associated with DMET genes or .. View More»
DOI:
10.4172/2157-7609.1000225