Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
+44 1300 500008
ISSN: 2161-038X
+44 1300 500008
Banafsheh Heidari
West Indies
Research Article
The Metformin-Induced Changes on BMI, TSH, and Thyroid Hormones Profile
of Patients with Polycystic Ovarian Syndrome
Author(s): Maryam Nemati, Shahnaz Nemati, Abolmajid Taheri and Banafsheh HeidariMaryam Nemati, Shahnaz Nemati, Abolmajid Taheri and Banafsheh Heidari
Objective: The aim of this prospective study was to investigate the effect of metformin on BMI, TSH, thyroid hormones profile, and some clinical symptoms in 32 women with PCOS. Methods: The patients received metformin at a dose of 500 mg/day which was gradually increased to 1500 mg/day and continued for 3 months. The level of BMI, TSH, T4, and T3 was measured at baseline, 3 months after treatment with metformin and 3 months after drug withdrawal. The association of metformin therapy with prevalence of constipation, hypersomnia, cold intolerance, and dry skin was also determined in these times. Results: Three months after treatment with metformin, mean BMI and TSH was significantly decreased from baseline to 28.34±2.5 kg/m2 and 2.27±0.89 μUI/ml, respectively. There was no significant difference in TSH levels before treatment and 3 months after drug withdrawal. Mean T3 .. View More»
DOI:
10.4172/2161-038X.1000191