Current Synthetic and Systems Biology
Open Access
ISSN: 2332-0737
ISSN: 2332-0737
Ashish Runthala
Birla Institute of Technology & Science,
Pilani
India
Research Article
Non-Linear and Misleading Template Scoring Criteria: Root Cause of
Protein Modelling Inaccuracies
Author(s): Ashish RunthalaAshish Runthala
Template based protein modelling is currently the most accurate as well as trustworthy method for predicting the correct protein conformations to bridge the constantly increasing gap between the number of experimentally solved protein structures and the count of protein sequences. Our best knowledge based prediction algorithms employing the templates are not highly proficient of consistently selecting the best scoring template(s) to construct a highly accurate protein model. Mutually contrary nature of generic and currently employed template assessment and selection scores further makes this essential modelling step a very tricky and fluky business. Precisely, the article briefly investigates and justifies the impact of fundamentally allowed degree of freedom of a template selection measure on the accuracy of constructed protein models. Several logical guidelines, normally overlooked .. View More»
DOI:
10.4172/2332-0737.1000121