Autism-Open Access
Open Access
ISSN: 2165-7890
ISSN: 2165-7890
Allison Bechard
Tanzania
Review Article
Modeling Restricted Repetitive Behavior in Animals
Author(s): Allison Bechard and Mark Lewis
Allison Bechard and Mark Lewis
Restricted, repetitive behavior is one of the three diagnostic domains for autism spectrum disorders, and commonly observed in a number of other neurodevelopmental disorders. Despite its clinical significance, effective treatments for restricted, repetitive behavior are limited including few, if any, pharmacological interventions with demonstrated efficacy. This is in large measure due to the lack of knowledge of the pathophysiological mechanisms that mediate the development and expression of repetitive behaviors in autism spectrum disorders. Therefore, animal models, particularly those that encompass both lower order and higher order repetitive behaviors, could be particularly useful. Such models could identify various potential etiologies, characterize commonalities in pathophysiology, identify novel potential therapeutic targets, and guide the development and validation of novel tr.. View More»
DOI:
10.4172/2165-7890.S1-006