Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Alexander Reis
Reis Augenklinik,
Eschnerstrasse 4, FL 9487 Bendern
Liechtenstein
Case Report
Atovaquone: A Valuable Therapeutic Option in Toxoplasma Retinochoroiditis
Author(s): Alexander Reis, Christophe Valmaggia, Tamer Tandogan, Karoline Rippel and Olja GirmannAlexander Reis, Christophe Valmaggia, Tamer Tandogan, Karoline Rippel and Olja Girmann
Background: Toxoplasma gondii is a leading cause of severe foodborne illness in first world countries and the most common cause of posterior uveitis. Neither a standard treatment protocol has been established so far, nor has the efficacy of the mostly applied medications and their combinations be proven in well-designed clinical trials. Atovaquone, a hydroxy-1,4-naphtoquinone, is a safe and effective treatment against tachyzoites and cyst forms of Toxoplasma, but it is only FDA and EMEA approved for the treatment of pneumocystis infections. We have started using Atovaquone in ocular toxoplasmosis on a regular, off-label basis in 1996.
Methods: We report about the use of Atovaquone 750 mg twice daily in punctate outer retinal toxoplamosis as well as in Toxoplasma retinochoroiditis resistant to four different antibiotic.. View More»
DOI:
10.4172/2155-9570.1000418