Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Akino Honbo
Japan
Research Article
Pharmacokinetic-Pharmacodynamic Analyses of Anti-diabetes, Glimepiride: Comparison of the Streptozotocin-Induced Diabetic, GK and Wistar Rats
Author(s): Akiko Kiriyama, Shunsuke Kimura, Chizuki Banba, Miki Yamakawa, Rie Yajima, Akino Honbo and Katsumi IgaAkiko Kiriyama, Shunsuke Kimura, Chizuki Banba, Miki Yamakawa, Rie Yajima, Akino Honbo and Katsumi Iga
Efficacy and safety of a drug and its plasma concentration are closely correlated, and plasma concentrations are used as an index of the drug’s effects. Therefore, it is important to understand the relationship between the drug’s plasma concentration and its effects. Plasma glucose control of diabetics retards its progression and glimepiride is widely used for its treatment. In the present study, pharmacokinetic-pharmacodynamic analysis of glimepiride was performed in Wistar rats, with normal plasma glucose levels (Normal), and streptozotocin-induced type 1 diabetes rats (Type 1) and type 2 diabetes GK rats (Type 2). The PK-PD model was structured to investigate time-dependent plasma glucose changes in relation to the plasma concentration, and the PK and PD characteristics of glimepiride were investigated.
PK analysis of glimepiride in the three groups showed no .. View More»
DOI:
10.4172/2157-7609.1000229