Journal of Leukemia
Open Access
ISSN: 2329-6917
+44 1300 500008
ISSN: 2329-6917
+44 1300 500008
Adam Bryant
Canada
Research Article
Thymic Immunophenotype, and Expression of CD4 and Myeloid Antigens is Associated with Outcome in Adult Patients with T–Cell Acute Lymphoblastic Leukemia
Author(s): Areej Al Mugairi, Bakul I Dalal, Steven Pi, Soo Yeon Lee, Nikisha S Khare, Jason Pal, Alok Vakil, Adam Bryant, Sally Lau and Yasser R Abou MouradAreej Al Mugairi, Bakul I Dalal, Steven Pi, Soo Yeon Lee, Nikisha S Khare, Jason Pal, Alok Vakil, Adam Bryant, Sally Lau and Yasser R Abou Mourad
Background: In adult patients with T?cell acute lymphoblastic leukemia (T?aALL), age, WBC count and cytogenetics are used for prognostic stratification. We report the prognostic significance of immunophenotype in T? aALL patients. Methods: We analyzed 27 T?aALL patients treated at the�Leukemia-BMT Program of British Columbia between 1989 and 2010 using a standardized protocol for diagnosis, treatment and follow up. The immunophenotyping raw data was re-analyzed to record positivity (?20% blasts positive), number of blasts positive, and intensity and homogeneity of expression. Thymic phenotype (TP) and expression of myeloid antigens (My+) were defined as any one of CD1a+ or dual�expression of CD4 and CD8, and any one of CD13+, CD33+ or CD117+ respectively. Results: Twenty-two (81%) T?aALL patients achieved complete remission (CR); of these, 7(32%) relapsed within 5-22 months (median 15 mo.. View More»
DOI:
10.4172/2329-6917.1000172