Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Abdel-Maksoud A Hussien
Egypt
Research Article
Cranberry Extract as a Functional Food in Treatment of Oxidative Stress in Iron-
Induced Hepatic Toxicity in Rats
Author(s): Abdel-Maksoud A Hussien, Mohammed Abdalla Hussein, Afaf D Abd El Mageed and Amira M Abdel-BakyAbdel-Maksoud A Hussien, Mohammed Abdalla Hussein, Afaf D Abd El Mageed and Amira M Abdel-Baky
The present study was to evaluate the protective role of cranberry extract against iron-induced hepatic toxicity in rats. Administration of iron sulfate (30 mg/kg body weight) orally for 21 days, led to significantly (p<0.01) increased in the levels of blood hemoglobin, glucose, lipid profile, plasma and hepatic lipid peroxidation, iron and transferrin. Also, oral administration of iron sulfate showed a significant decrease (p<0.01) in the levels of plasma and liver enzymatic and non-enzymatic antioxidants. Administration of cranberry extract at different doses (75 mg/kg and 150 mg/kg body weight) significantly (p<0.01) restore the levels of plasma and hepatic markers, lipid profile, lipid peroxidation levels as well as increased the levels of plasma and hepatic enzymatic antioxidants and non-enzymatic antioxidants with normalize plasma iron and transferrin concentration in b.. View More»
DOI:
10.4172/2157-7609.1000191