Circulating levels of oxidized low density lipoprotein β2-glycoprotein I complex (oxLDL-GP) have been previously correlated with adverse cardio-vascular events. This study measured the effect of consuming various dietary oil capsules on oxLDL-GP serum concentrations in healthy human subjects. The dietary oil capsules tested were: enzymatically liberated salmon oil, as a proxy for the entire lipid soluble fraction of whole salmon, high DHA algae oil and standard 18/12 fish oil. Our results showed that only the enzymatically liberated salmon oil had a significant lowering of circulating serum concentration ofoxLDL-GP, after 3 weeks of treatment. This result lends support to the developing theory, that eating whole functional foods for their nutritive and health benefiting effects may not be reproduced by highly-refined supplements derived from these foods.