Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Diabetes mellitus is a progressive chronic disease associated with enhanced levels of fasting glucose, HbA1C, and insulin resistance. Despite valuable recommendations of changes in diet and lifestyle, the risk of developing diabetes type II continues to increase. Risk factors such as elevated levels of oxidative stress and chronic inflammation, intestinal dysbiosis, omega-3-fatty acids dysfunction, and reduced secretion of insulin contribute to the development and progression of diabetes. Addressing one of these defects at a time may not produce an optimal benefit. To prevent and improved treatment of diabetes, this review proposes
(a) changes in diet and lifestyle,
(b) supplementation with a micronutrient mixture which would simultaneously reduce oxidative stress and chronic inflammation,
(c) probiotics with prebiotics which would reverse the intestinal dysbiosis,
(d) omega-3-fatty acids which would directly activate the insulin receptor-linked signaling protein AKT leading to the entry of glucose inside the cells in patients with insulin resistance, and
(e) collagen peptides which increase the secretion of insulin by inhibiting Dipeptidyl Peptidase-4 (DPP-4) activity.
Despite diabetic medications, complications such as retinopathy, nephropathy, peripheral neuropathy, and heart disease continue to develop due to resistance to medications. The proposed plan in combination with drugs may improve their effectiveness.
Published Date: 2023-10-30; Received Date: 2023-10-02