Sesame which is known for properties of good health consists of a plethora of nutrients viz., proteins, carbohydrates, antioxidants, lignans, tocopherols and other micronutrients. Benefits of this enigmatic crop include properties of anticancer, antioxidative, antiimmunoregulation and antihypersensitivity. Covering wide agro ecological regions of the world, different varieties of sesame seeds are available. They are seen growing in different parts of the world, where India being one of the major producers. The oil from this seed can be extracted by simple processes of solvent extraction and expelling. Alternatively, as the technology has advanced, supercritical extraction can also be employed. Sesame which is considered as an extremely beneficial medicine has inherent power to cure many diseases. Sesame has a ray of health benefits in lowering cholesterol, controlling blood pressure, dermatological disease management and many more areas. This review gives an overall impact about sesame, properties and its role in various sections.