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Comparing the Effectiveness of Cognitive Behavioral Therapy with
International Journal of School and Cognitive Psychology

International Journal of School and Cognitive Psychology
Open Access

ISSN: 2469-9837

+44 1478 350008

Research Article - (2018) Volume 5, Issue 1

Comparing the Effectiveness of Cognitive Behavioral Therapy with Acceptance and Commitment Therapy on Reduction of Social Anxiety Disorder Symptoms in University Students

Mohammad Reza Yabandeh, Hossein Bagholi*, Siros Sarvghad and Maryam Koroshnia
Department of Psychology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran, E-mail: YabandehMR@gmail.com
*Corresponding Author: Hossein Bagholi, Department of Psychology, Islamic Azad University, Marvdasht, Iran, Tel: 09177000288 Email: ,

Abstract

Background: Social anxiety disorder is one of the most common chronic anxiety disorders with a significant fear or anxiety that leads to a long period of disability and the sufferer suffers a lot of problems in terms of personal, occupational and social performance
Objectives: The purpose of present study was to compare the effectiveness of cognitive behavioral group therapy and acceptance and commitment group therapy on reducing of social anxiety symptoms in university students with social anxiety disorder.
Methods: In this research, a semi-experimental interventional method was used using two groups of experimental and one control group. A sample of 45 students with social anxiety disorder was selected by convenience sampling method and then randomly assigned to two experimental and one control groups. The Social Phobia Inventory (SPIN) was used for data collection in order to assess the amount of social anxiety. The pre-test and post-test scores were analyzed using covariance test.
Results: The results showed that, both treatment groups outperformed control group, with no differences observed between CBT group and ACT group. Although ACT group slightly outperformed CBT group but the difference was not statistically significance.
Conclusion: Findings shows that the two therapeutic approaches are equally effective in reducing the symptoms of social anxiety, and ACT can be a good alternative CBT in the treatment of social anxiety disorder.

Keywords: Acceptance and commitment therapy; Cognitive behavioral therapy; Social anxiety

Materials and Methods

This research is quasi-experimental in which the pretest-posttest control group design was used. Independent variable in this study was treatment (acceptance and commitment therapy and cognitive behavioral therapy) and dependent variable was, changes in social phobia inventory (SPIN) scores as a result of the application of two different treatment methods.

The statistical population consisted of all undergraduate students of Islamic Azad University of Marvdasht and Shiraz, in 2016.

The sampling was done in two stages: in the first stage, 470 students were selected by convenience method. Students who got high scores in SPIN (35-40 or higher) were identified and were clinically interviewed (according to the criteria of the Diagnostic Statistical Manual, Fifth Edition). The criteria for entry to the experimental group were: studying in university, not taking psychiatric drugs, not having other psychological and personality disorder, not participating simultaneously in other therapy programs and not receiving individual or personal counseling. Exclusion criteria were active suicidal ideation, severe depression, history of bipolar disorder or psychosis, substance abuse or dependence within the last 6 months. Upon identifying students with social anxiety disorder and receiving the final consent of the individuals to participate in the research, in the second stage of sampling, 45 students with social anxiety disorder were randomly assigned to three groups as follows: 15 in the experimental group ACT and 15 in the experimental group CBT and 15 were assigned into control group.

All three groups were assessed prior to treatment (Pre), by social anxiety inventory (SPIN) [36]. Then one of the experimental groups received CBT based on Hoffman & Otto’s practitioner’s Guide [5], and the second experimental group received ACT based on the Eifert and Forsyth practitioner’s Guide [23]. For twelve weekly, 2-hour, group therapy sessions1 but the control group did not receive any intervention. At the end of treatment, the subjects in all groups completed the social anxiety inventory (SPIN) again in the post-test stage and finally the obtained data was analyzed by covariance analysis method (Table 1).

Cognitive Behavioral Therapy for Social Anxiety Disorders Based on Hoffman and Otto Guidelines (2008)
Session 1: Establishing relationship and introducing a therapeutic model with special emphasis on exposure
Session 2: Reviewing the homework of the previous session and the therapeutic model, practicing exposure in the session by asking the members to explain the therapeutic model and its logic, and at the end of the session assigning homework
Session 3-6: Creating enough anxiety for each exposure exercise and at the end of the session assigning homework
Session 7-11: Introducing exposures based on the fear hierarchy and asking each patient to anticipate the following: 1. Average and Maximum Anxiety During Exposure? 2. Consequence of the situation? 3. How long will these consequences take? And finally assigning homework
Session 12: Summarize the progress of each group member with regard to the independent practice and the positive skills that each member has learned and discuss what parts and kinds of anxiety has been overcome and what remains.
Acceptance and commitment therapy for anxiety disorders: a manual by Eifert and Forsyth (2005)
Session 1: focused on psychoeducation, experiential exercises, and discussion of acceptance and valued action.
Sessions 2–3: explored creative hopelessness, or whether previous efforts to control anxiety had“worked” and how such efforts had led to the reduction of valued life activities and encouraged acceptance.
Sessions 4 and 5: emphasized mindfulness, acceptance, and cognitive defusion, or theprocess of experiencing anxiety-related language [e.g., thoughts,self-talk, and so forth] as part of the broader, ongoing stream ofpresent experience rather than getting stuck in responding to its literal meaning.
Sessions 6–11: continued to hone acceptance, mindfulness, and defusion, and added values exploration and clarification with the goal of increasing willingness to pursue valued life activities. Behavioral exposures, including interoceptive, in vivo,and imaginal, were used to practice making room for, mindfully observing, and accepting anxiety and to practice engaging in valued activities while experiencing anxiety.
Session 12: reviewed what worked and how to continue moving forward.

Table 1: Summary of treatment sessions.

It should be mentioned that the control group had already been informed about the necessity of receiving treatment, after post assessment, they were offered treatment free of charge, and were able to choose either CBT or ACT at the end of the research project.

Instruments

The amount of social anxiety was measured by social anxiety inventory (SPIN), which is a self-assessment scale of 17 items and total scores can range from 0 to 68. SPIN was designed by Canner et al. in 2000 to assess social anxiety and it’s very sensitive to reduction of the symptoms of social anxiety over time. One of its uses is to test the response to treatment in social anxiety disorder. It is a useful screening tool for distinguishing between people with and without social anxiety, scores above 51 are considered very severe social anxiety and scores between 41 to 50 moderate, 21 to 30 low and less than 20 normal, the cut point 40 with an accuracy of 80% can distinguish people with or without Social phobia [36]. Results from the original validation study suggest that the SPIN possesses strong internal consistency, test–retest reliability, convergent validity, discriminative validity, construct validity, and sensitivity for measuring change following pharmacological treatment [37].

Results

The assumptions of covariance analysis, the final analysis results are Covariance analysis was used to analyze the data and compare the experimental and control groups. By confirming presented in Table 2.

Tests of Between-Subjects Effects
Source Type III Sum of Squares df Mean Square F Sig. Eta Squared
Group 64.657 2 32.329 9.169 0.001 0.372
SPIN_Pre 338.976 1 338.976 96.138 0.000 0.756
Group * SPIN_Pre 10.707 2 5.352 1.523 0.235 0.089

Table 2: Covariance analysis.

As shown in Table 2, the value of F for the difference between the groups (control and experiment) is significant at the significance level of ≤ 0.001. This means that there is a significant difference (with pre-test factor control) between the social anxiety scores of the experimental and control group. Therefore, it is confirmed that therapy sessions have been effective. Another indicator to be considered is the effect size, which is indicated in the table as “ETA”. The value of ETA squared is 0.372, which in percentage will be 37%, meaning that 37% of the changes in social anxiety scores are due to the implementation of the treatment.

Subsequently, the difference between pairs of groups was investigated using post hoc test. The results of the follow-up test are presented in Table 3.

Groups Mean (differences) Sig. 95% confidence interval for the difference between the two groups
Lower limit Upper limit
CONTROL CBT *3.98 0.0001 2.44 5.51
ACT *4.68 0.001 3.06 6.19
CBT CONTROL *3.98 0.0001 -5.51 -2.44
ACT 0.65 0.395 -0.89 2.18
ACT COTROL *-4.63 0.001 -6.19 -3.06
CBT -0.65 0.395 -2.18 0.89

*The difference is significant at the 5% error rate

Table 3: Post-test results.

The results of the post hoc test in Table 3 show that there is a significant difference between the control group and the CBT group, as well as between the control group and the ACT group at a meaningful level of ≤ 0.001, and both therapeutic methods have been effective. Although the effect ACT was slightly higher than CBT, but the difference between the two treatment groups was not significant.

Discussion

The aim of this study was to compare the effectiveness of cognitive behavioral group therapy and Acceptance and commitment group therapy in reducing the social anxiety symptoms in students with social anxiety disorder. The results showed that both approaches reduced the social anxiety symptoms compared to control group. Initially, in order to determine the effectiveness of each approach separately, it can be said, based on literature, that the results obtained using ACT approach [38,39] were consistent with the results obtained using CBT approach [16,40,41].

The findings of the present study were consistent with the findings of study carried out by Forman, Herbert, Moitra, Yeomans, and Geller [33] which compared the effects of ACT and CBT approaches in outpatients with moderate to high levels of depression and anxiety without being diagnosed with depression and anxiety; while they were inconsistent with the study carried out by Lappalainen et al. [42] which studied only 28 patients with different disorders individually treated by different therapists and indicated that the symptoms reduced more significantly in patients treated with ACT than in patients treated with CBT. Although, in the present study, the symptoms of social anxiety reduced more significantly in ACT group than in CBT, but the difference was insignificant. These are consistent with the findings of following studies: Arch et al. [34] compared the effectiveness of ACT with CBT on a sample population of individuals with anxiety disorders; Craske et al. [3] investigated the interventions and consequences of cognitive behavioral therapy and Acceptance and commitment therapy in treatment of social anxiety disorder; Kocovski, Fleming, Hawley, Huta and Antony [43] compared acceptance and commitment group therapy with cognitive behavioral group therapy on social anxiety. In order to further clarify the findings, we can mention the similarities between the two approaches and common processes and methods in these two approaches including that both approaches provide a context which identify the cognition as the product of a system rather the expression of internal truth; both approaches believe in inefficiency of automatic, inflexible responses to experience which enforces the problems [31]. The other common feature in these approaches is exposure to stressful thoughts rather controlling or suppressing them, which is considered to be the main treatment factor in the model Hofmann and Otto model [37] used in this research, though with a different logic and different methodology; in CBT, exposure takes place with the aim of reducing anxiety and gaining control over fear, anxiety, evaluating the individuals’ catastrophic predictions [44] and avoiding social situations is considered to maintain anxiety [37]; but in ACT, the aim of exposure to or experiential acceptance which is studied as a change mechanism [32] is to increase the individuals’ interest in experiencing internal incidents as they are accomplishing what is of value to them in life and what is consistent with their life values [43]. In the present study, one important intervention in therapy sessions for both experimental groups were exposure. Given the potential of exposure in treating the anxiety disorders (For example, Norton, Price, [45], it is possible that this shared treatment component counterbalances the differences in two approaches and leads to equal effectiveness in both therapies. Furthermore, in a study carried out by Burton, Schmertz, Price, Masuda, and Anderson [46] on the relationship between mindfulness and fear of negative evaluation in CBT therapy on social anxiety disorder, it was shown that although the mindfulness is associated with the fear of negative evaluation as a main factor of social anxiety disorder, better mindfulness did not moderate treatment outcome. The findings confirmed the aforesaid results given that mindfulness is an important factor in ACT therapy [47].

Moreover, several authors have suggested that exposure and cognitive restructuring are difficult to differentiate both conceptually and practically, since both specifically aim to provide new learning experiences that contradict patients’ beliefs about the likelihood and cost of negative social outcomes [37,48]. Exposure has been shown to lead to cognitive change [49], and cognitive techniques, especially behavioral experiments, often involve exposure-like experiences. In addition, ACT emphasizes eliminating tendencies to avoid or escape from unpleasant emotions and an emphasis on tolerating unpleasant feelings which is so similar to what exposure asserts. Based on this once more we can conclude that a similarity of these two approaches can lead to similar results.

However, the findings in literature are inconsistent. For example, Kocovski, Fleming, Hawley, RingoHo, Antony [43] questioned whether, in social anxiety disorder, cognitive reappraisal is considered to be the unique mechanism of change in Cognitive Behavioral Group Therapy and mindfulness and acceptance in Mindfulness and Acceptance-based Group Therapy? Cognitive reappraisal was reported to be effective only in cognitive behavioral group therapy while mindfulness and acceptance were an effective mechanism in both therapies.

Limitation

While there have been many studies on the effectiveness of each approach on various disorders individually, for example, Bluett, Homan, Morrison, Levin, and Twohig, [50] reported that ACT as the effective therapy on anxiety disorders, but lack of studies comparing the effectiveness of these two approaches on a specific disorder is considered to be the limitation of the present study. Also, the sample population entirely consisted of university students which are considered to be a specific population which in turn limits the potential of generalizing the results to other populations; accordingly, it is suggested that other populations also be used in future studies. Lack of facilities for at least 3-month follow-up is also another limitation of the study and hence it cannot be determined whether these two approaches are equally effective in reducing the symptoms of social anxiety disorder and the results obtained will remain stable. It is possible to obtain different results by extensive research and follow-up as Arch et al. [34] indicated after a 12-month follow-up that the symptoms of social anxiety are reduced more significantly in ACT group compared to CBT group.

Conclusion, Future Directions and Recommendations

The aim of present study was to compare the effectiveness of cognitive behavioral group therapy and acceptance and commitment group therapy on reducing of social anxiety symptoms in university students with social anxiety disorder. The findings showed that the two therapeutic approaches were equally effective in reducing the symptoms of social anxiety in university students. While acceptance and commitment group therapy, slightly outperformed the cognitive behavioral group therapy in the treatment of social anxiety disorder in university students, still further studies in this area is needed to come up with more clear result.

We, the authors recommend that the same study replicated with different population in order to find out whether the result obtained will be of any dereference.

References

  1. McEvoy PM, Grove R, Slade T (2011) Epidemiology of anxiety disorders in the Australian general population: findings of the 2007 Australian National Survey of Mental Health and Wellbeing. Aust N Z J Psychiatry 45: 957-967
  2. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, et al. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62: 593-602
  3. Craske MG, Niles AN, Burklund LJ, Wolitzky-Taylor KB, Vilardaga JC, et al. (2014) Randomized controlled trial of cognitive behavioral therapy and acceptance and commitment therapy for social phobia: outcomes and moderators. J Consult Clin Psychol 82: 1034-1048.
  4. American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders (5th edn). Arlington, VA: American Psychiatric Publishing.
  5. Hofmann Stefan G, Otto Michael W (2007) Cognitive behavioral therapy for social anxiety disorder. New York: Routledge Press, USA.
  6. Ruscio AM, Brown TA, Chiu WT, Sareen J, Stein MB, et al. (2008) Social fears and social phobia in the USA: results from the National Comorbidity Survey Replication. Psychol Med 38: 15-28.
  7. National Collaborating Centre for Mental Health (UK) (2013) Social Anxiety Disorder: Recognition, Assessment and Treatment. Leicester (UK): British Psychological Society; National Institute for Health and Care Excellence: Clinical Guidelines.
  8. Gültekin BK, Dereboy IF (2011) The prevalence of social phobia, and its impact on quality of life, academic achievement, and identity formation in university students. Turk Psikiyatri Derg 22: 150-158.
  9. Hofmann Stefan G (2007) Cognitive factors that maintain social anxiety disorder: A comprehensive model and its treatment implications. Cogn Behav Ther 36: 193-209.
  10. Clark DM, Ehlers A, McManus F, Hackmann A, Fennell M, et al. (2003) Cognitive therapy versus fluoxetine in generalized social phobia: a randomized placebo-controlled trial. J Consult Clin Psychol 71: 1058-1067.
  11. Philippe GR, Michal Z, Hooria J, Justin W, Richard HG, et al. (2014) Impact of cognitive-behavioral therapy for social anxiety disorder on the neural bases of emotional reactivity to and regulation of social evaluation. Behav Res Ther 62: 97-106.
  12. Borge FM, Hoffart A, Sexton H, Clark DM, Markowitz JC, et al. (2008) Residential cognitive therapy versus residential interpersonal therapy for social phobia: a randomized clinical trial. J Anxiety Disord 22: 991-1010.
  13. Kampmann IL, Emmelkamp PM, Hartanto D, Brinkman WP, Zijlstra BJ, et al. (2016) Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial. Behav Res Ther 77: 147-156.
  14. Hofmann SG, Smits JA (2008) Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry 69: 621-632.
  15. Butler AC, Chapman JE, Forman EM, Beck AT (2006) The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clin Psychol Rev 26: 17-31.
  16. Hofmann SG, Asnaani A, Vonk IJ, Sawyer AT, Fang A (2012) The efficacy of cognitive behavioral therapy: A review of meta-analyses. Cognit Ther Res 36: 427-440
  17. Blanco C, Heimberg RG, Schneier FR, Fresco DM, Chen H, et al. (2010) A placebo-controlled trial of phenelzine, cognitive behavioral group therapy, and their combination for social anxiety disorder. Arch Gen Psychiatry 67: 286-295.
  18. Tolin DF (2010) Is cognitive-behavioral therapy more effective than other therapies? A meta-analytic review. Clin Psychol Rev 30: 710-720.
  19. Barlow David H (2014) Clinical Handbook of Psychological Disorders, (5th edn): A Step-by-Step Treatment Manual. New York: Guilford Press, USA.
  20. Dimidjian S, Hollon SD, Dobson KS, Schmaling KB, Kohlenberg RJ, et al. (2006) Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression. J Consult Clin Psychol 74: 658-670.
  21. Hayes SC, Strosahl K, Wilson KG (1999) Acceptance and commitment therapy: An experiential approach to behavior change. New York: Guilford Press, USA.
  22. Darlymple K (2007) Acceptance and commitment therapy for generalized social anxiety disorder: A pilot study. Behav Modif 31: 543-568.
  23. Eifert GH, Forsyth JP, Arch J, Espejo E, Keller M, et al. (2009) Acceptance and commitment therapy for anxiety disorders: Three case studies exemplifying a unified treatment protocol. Cognitive Behavioral Practice 16: 368-385. 
  24. Roemer L, Orsillo SM, Salters-Pedneault K (2008) Efficacy of an acceptance-based behavior therapy for generalized anxiety disorder: evaluation in a randomized controlled trial. J Consult Clin Psychol 76: 1083-1089.
  25. Hill ML, Masuda A, Melcher H, Morgan J, Twohig MP (2014) Acceptance and commitment therapy for women diagnosed with binge eating disorder: A case-series study. Cognitive and Behavioral Practice. Psychology Faculty Publications. Paper 89
  26. Twohig MP, Hayes SC, Masuda A (2006) Increasing willingness to experience obsessions: acceptance and commitment therapy as a treatment for obsessive-compulsive disorder. Behav Ther 37: 3-13.
  27. Hayes L, Boyd CP, Sewell J (2011) Acceptance and commitment therapy for the treatment of adolescent depression: A pilot study in a psychiatric outpatient setting. Mindfulness 2: 86-94.
  28. Hayes SA, Orsillo SM, Roemer L (2010) Changes in proposed mechanisms of action during an acceptance-based behavior therapy for generalized anxiety disorder. Behav Res Ther 48: 238-245.
  29. Hayes SC, Villatte M, Levin M, Hildebrandt M (2011) Open, aware, and active: Contextual approaches as an emerging trend in the behavioral and cognitive therapies. Ann Rev Clinical Psychol 7: 141-168.
  30. Hayes SC, Smith S (2005) Get out of your mind and into your life: The new Acceptance and Commitment Therapy. Oakland, CA: New Harbinger Publication.
  31. Herbert JD, Gaudiano BA, Forman EM (2013) The importance of theory in cognitive behavior therapy: a perspective of contextual behavioral science. Behav Ther 44: 580-591
  32. Hayes SC, Luoma J, Bond F, Masuda A, Lillis J (2006) Acceptance and Commitment Therapy: Model, processes, and outcomes. Behaviour Res Therapy 44: 1-25.
  33. Forman EM, Herbert JD, Moitra E, Yeomans PD, Geller PA (2007) A randomized controlled effectiveness trial of acceptance and commitment therapy and cognitive therapy for anxiety and depression. Behavior Modification. 31: 772-799.
  34. Joanna A, Georg EH, Carolyn D, Jennifer C VP, Raphael RD, et al. (2012) Randomized clinical trial of cognitive behavioral therapy (CBT) versus acceptance and commitment therapy (ACT) for mixed anxiety disorders. J Consult Clin Psychol 80: 750-765.
  35. Ozsaker M, Muslu GK, Kahraman A, Beytut D, Yardimci F, et al. (2015) A study on the effects of loneliness, depression and perceived social support on. problematic Internet use among university students. Anthropologist.
  36. Connor KM, Davidson JR, Churchill LE, Sherwood A, Foa E, et al. (2000) Psychometric properties of the Social Phobia Inventory (SPIN). New self-rating scale. Br J Psychiatry 176: 379-386.
  37. Sadegh S, Normohammad B (2015) Effectiveness of group therapy and stress coping skills on social anxiety of students. Knowledge and Research in Applied Psychology 15: 96-104.
  38. Majid PO (2011) The effectiveness of group therapy on acceptance and commitment to students' social phobia. J Knowledge Health 2: 1-5.
  39. Osman A, Barrios FX, Aukes D (2007) Psychometric evaluation of the social phobia and anxiety inventory in college students. J Clin Psychol 51: 235-243.
  40. Mahmoud AM, Touraj H, Nusratibad Azam G (2017) The effectiveness of cognitive-hygiene-based treatment based on huffman's model on reducing the fear of negative evaluation and self-focused focus on social anxiety disorder. J Clinical Psychol 33: 101-111.
  41. Abdi M (2014) Interpretation bias in people with social phobia. Master's thesis for clinical psychology. Not printed. Tehran Psychiatric Institute.
  42. Lappalainen R, Lehtonen T, Skarp E, Taubert E, Ojanen M, et al. (2007) The impact of CBT and ACT models using psychology trainee therapists: a preliminary controlled effectiveness trial. Behav Modif 31: 488-511.
  43. Kocovski NL, Fleming JE, Hawley LL, Huta V, Antony MM (2013) Mindfulness and acceptance-based group therapy versus traditional cognitive behavioral group therapy for social anxiety disorder: a randomized controlled trial. Behav Res Ther 51: 889-898.
  44. Eifert GH, Forsyth JP (2005) Acceptance and commitment therapy for anxiety disorders: A practitioner's treatment guide to using mindfulness, acceptance, and values-based behavior change strategies. Oakland, CA: New Harbinger Publications.
  45. Norton PJ, Price EC (2007) A meta-analytic review of adult cognitive-behavioral treatment outcome across the anxiety disorders. J Nerv Ment Dis 195: 521-531.
  46. Burton M, Schmertz SK, Price M, Masuda A, Anderson PL (2013) The relation between mindfulness and fear of negative evaluation over the course of cognitive behavioral therapy for social anxiety disorder. J Clin Psychol 69: 222-228.
  47. Hayes SC, Follette VM, Linehan MM (2004) Mindfulness and acceptance: Expanding the cognitive-behavioral tradition. New York: Guilford Press, USA.
  48. Rodebaugh TL, Holaway RM, Heimberg RG (2004) The treatment of social anxiety disorder. Clin Psychol Rev 24: 883-908.
  49. Ponniah K, Hollon SD (2008) Empirically supported psychological interventions for social phobia in adults: a qualitative review of randomized controlled trials. Psychol Med 38: 3-14.
  50. Bluett EJ, Homan KJ, Morrison KL, Levin ME, Twohig MP (2014) Acceptance and commitment therapy for anxiety and OCD spectrum disorders: an empirical review. J Anxiety Disorder 28: 612-624.
Citation: Yabandeh MR, Bagholi H, Sarvghad S, Koroshnia M (2018) Comparing the Effectiveness of Cognitive Behavioral Therapy with Acceptance and Commitment Therapy on Reduction of Social Anxiety Disorder Symptoms in University Students. Int J Sch Cogn Psychol 5: 208.

Copyright: ©2018 Yabandeh MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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