Journal of Clinical Trials
Open Access
ISSN: 2167-0870
+44 1478 350008
ISSN: 2167-0870
+44 1478 350008
Department of General Medicine and Primary Care, Tokushima University Hospital, Tokushima, Japan
Research Article
Strict Gluten-Restricted Diet Reduces Disease Activity of Rheumatoid Arthritis with Low Anti-Cyclic Citrullinated Peptide Antibodies
Author(s): Kenji Tani*, Yoshihiro Okura, Shingo Kawaminami, Keisuke Kawahito, Keisuke Kondo, Ryosuke Takahashi, Ryo Tabata, Teruki Shimizu and Harutaka Yamaguchi
Objective: To investigate the efficacy of gluten-restricted diet for the disease activity of Rheumatoid Arthritis (RA) and clinical factors corresponding to the response.
Methods: Sixty three patients with active RA were included in this study. At baseline, we gave the patients the information about gluten-free and-contained foods, and asked them to refrain from the daily gluten consumption during the experimental period.
Results: The 16-week gluten-restricted diet significantly improved DAS28-CRP and CDAI scores. The percentages of patients achieving DAS28-CRP- and CDAI-defined remission or LDA were significantly increased at Week 16. When the self-reported levels about adherence to the gluten-restricted diet were divided into two categories, a significant improvement in DAS28- CRP, CDAI, and EULAR treatment respo.. View More»