Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Department of Internal Medicine, National Institute of Health and Medical Research, Paul Sabatier University, Toulouse, France
Research Article
Galanin Dictates Metabolic Reprogramming in Aberrantly Activated Fibroblasts to Reverse Established Cardiac Fibrosis
Author(s): Lesia Savchenko, Rodica Anesia, Andrei Timotin, Alexander Kel, Dimitri Marsal, Ilenia Martinelli, Jerome Roncalli and Oksana Kunduzova*
Myocardial fibrosis is a common motif in Heart Failure (HF)-related fatalities. Persistent activation of fibroblasts triggers excessive fibrotic cascades culminating in cardiac fibrosis and dysfunction. However, molecular mechanisms orchestrating fibroblast activation are still obscure and as a result, effective strategies for limiting or reversing fibrosis are lacking. Here, we decrypted the metabolic phenotype of fibrosis-remodelled heart and unlocked bioactive peptide galanin as a metabolic checkpoint in aberrant fibroblast activation dictating fibrotic tissue remodeling. Integrated analysis of RNA-seq revealed a predominant role of galanin in metabolism of cardiac fibroblasts. Functional studies found that galanin calibrates metabolc reprogramming during fibroblast phenotypic switching from naïve to activated phenotype promoting myocardial fibrosis. In a mouse model of HF, ch.. View More»
DOI:
10.35248/2161-1025.25.15.344