Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Department of Cardiology, GeneXplain GmbH, Wolfenbuttel, Germany
Research Article
Galanin Dictates Metabolic Reprogramming in Aberrantly Activated Fibroblasts to Reverse Established Cardiac Fibrosis
Author(s): Lesia Savchenko, Rodica Anesia, Andrei Timotin, Alexander Kel, Dimitri Marsal, Ilenia Martinelli, Jerome Roncalli and Oksana Kunduzova*
Myocardial fibrosis is a common motif in Heart Failure (HF)-related fatalities. Persistent activation of fibroblasts triggers excessive fibrotic cascades culminating in cardiac fibrosis and dysfunction. However, molecular mechanisms orchestrating fibroblast activation are still obscure and as a result, effective strategies for limiting or reversing fibrosis are lacking. Here, we decrypted the metabolic phenotype of fibrosis-remodelled heart and unlocked bioactive peptide galanin as a metabolic checkpoint in aberrant fibroblast activation dictating fibrotic tissue remodeling. Integrated analysis of RNA-seq revealed a predominant role of galanin in metabolism of cardiac fibroblasts. Functional studies found that galanin calibrates metabolc reprogramming during fibroblast phenotypic switching from naïve to activated phenotype promoting myocardial fibrosis. In a mouse model of HF, ch.. View More»
DOI:
10.35248/2161-1025.25.15.344