Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
ISSN: 2157-7064
Export Inspection Agency, Kochi, Kerala, India
Research Article
Comprehensive Method Validation for the Determination of As, Cd, Hg and Pb in Cephalopods with its Applicability in Crustaceans and Fish Using ICPMS: The Role of Measurement Uncertainty for Reporting Statement of Conformity
Author(s): Kajan Kumar, Anoop A. Krishnan*, B. Vijaykumar, Lijo John, M. Kaliraj, T. Maheswara Rao, Jayapalan G and J.S. Reddy
A simple, sensitive, accurate and precise Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) method after microwave-assisted digestion was validated comprehensively for determination of arsenic, cadmium, mercury and lead in cephalopods and its applicability in crustaceans and fin fish samples. The performance characteristics like specificity, trueness, recovery, repeatability and intermediate repeatability with evaluation of HORRAT, Limit of Determination (LOD), Limit of Quantification (LOQ), standard measurement uncertainty and fitness for purpose is reported. The results of method validation demonstrated that the method complies with the performance criteria as per European Commission regulation 333/2007/EC. The ERM-CE278K (Mussel Tissue) certified reference material was used to evaluate trueness of the method. The mean recovery ranged between 82 to 120%. The HORRAT values were l.. View More»
DOI:
10.35248/2157-7064.22.13.486