Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Zeinab Abd El-Rehim Mohamed
Faculty of Medicine,
Egypt
Research Article
Effects of Exposure to Plasticizers Di-(2-Ethylhexyl) Phthalate and Trioctyltrimellitate on the Histological Structure of Adult Male Albino Rats
Author(s): Azza Saad Shehata, Zeinab Abd El-Rehim Mohamed, Manal Reda Abd El-Haleem and Mai Amin SamakAzza Saad Shehata, Zeinab Abd El-Rehim Mohamed, Manal Reda Abd El-Haleem and Mai Amin Samak
Di (2-ethylhexyl) phthalate (DEHP) and Trioctyltrimellitate (TOTM) are plasticizers used to increase the flexibility of polyvinyl chloride. Their wide commercial usage carries high risk of human exposure. This work aimed to investigate histological changes of rat’s liver upon DEHP and TOTM exposure. 36 adult male albino rats were classified into 3 equal groups; control group, group II (given DEHP 300 mg/kg) and Group III (given TOTM 300 mg/ kg) orally for 4 weeks. Half of the animals were sacrificed after one day of last dose (subgroups IIA & IIIA) and the remaining were left for another 4 weeks for recovery (subgroups IIB & IIIB). Liver specimens were examined by light and electron microscopes and immunohistochemical stain for hepatocyte paraffin -1 (Hep Par-1). By examination of subgroup IIA all rats’ liver showed focal changes. Dramatically affected lobules reve.. View More»
DOI:
10.4172/2161-0495.1000169