Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Uno Imaizumi
82 Inaoka-Cho, Yokosuka, Kanagawa 238-8580
Japan
Research Article
Effects of Ischemic and Sevoflurane-induced Preconditioning on Myocardial Infarction and Arrhythmias in Rabbits In Vivo
Author(s): Takayuki Miura, Uno Imaizumi, Munetaka Furuya, Jun Shirahama, Hirofumi Arisaka and Kazu-ichi YoshidaTakayuki Miura, Uno Imaizumi, Munetaka Furuya, Jun Shirahama, Hirofumi Arisaka and Kazu-ichi Yoshida
Objectives: The present study aimed to investigate whether ischemic or sevoflurane-induced preconditioning exerts infarct size limiting effects and depresses ischemia-reperfusion arrhythmias through opening of mitochondrial KATP channels in rabbits in vivo.
Methods: Rabbits anesthetized with ketamine and xylazine given intramuscularly underwent 30 min of left anterior descending coronary artery (LAD) occlusion followed by 3 hrs of reperfusion. Before this, rabbits were randomized into one of five groups. Control rabbits received no intervention before 30 min LAD occlusion and 3 h reperfusion (Group-C). The ischemia-preconditioned (IP) rabbits underwent 5 min LAD occlusion followed by 10 min of reperfusion before prolonged ischemia-reperfusion (Group-IP). In the sevoflurane (S)–preconditioned group, 30 min of sevoflurane exposure at a 1.. View More»
DOI:
10.4172/2155-6148.1000361