Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Uduak O. Luke
Nigeria
Research Article
Protective Effect of Vitamins C and E against Nitrocellulose Thinner Induced
Nephrotoxicity in Albino Wistar Rats
Author(s): Friday E. Uboh, Saviour U. Ufot, Uduak O. Luke, Godwin O. Igile and Chinelo M. OzojieFriday E. Uboh, Saviour U. Ufot, Uduak O. Luke, Godwin O. Igile and Chinelo M. Ozojie
Effect of vitamins C (vitamin C) and E (vitamin E) on nitrocellulose thinner (NCT)-induced nephrotoxicity in male rats was assessed. Six groups of six rats each, were orally administered 0.5 ml distilled water, 0.5 ml soybean oil, 40.0 mg NCT/kg bwt, 40.0 mg NCT/kg bwt+200 mg vitamin C/kg bwt, 40.0 mg NCT/kg bwt+200 IU vitamin E/kg bwt, and 40.0 mg NCT/kg bwt+200 IU vitamin E+200 mg vitamin C/kg bwt, respectively, for 30 days. The animals were sacrificed, 24 hours after last experimental treatments, blood and kidney tissues were collected for analyses of indicators of nephrotoxicity using standard methods. The results showed a significant (p<0.05) increase in serum creatinine (sCr), urea, uric acid, K+, HCO3 - and Cl- and decrease in serum Na+ levels, as well as severe renal histological changes in rats exposed to NCT only, compared to the values obtained for the control groups rec.. View More»
DOI:
10.4172/2161-0495.1000280