Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
+44 1223 790975
ISSN: 2167-7700
+44 1223 790975
Toshihiko Hirano
School of Pharmacy,
1432-1 Horinouchi, Hachioji, Tokyo 192-0392
Japan
Commentary
Polymethyoxy Flavonoids: Possible Candidates for Overcoming Drug Resistance
Author(s): Toshihiko HiranoToshihiko Hirano
The success of chemotherapy in cancer treatment is frequently limited by intrinsic or acquired multidrug resistance due to increased expression of a plasma membrane P-glycoprotein . P-glycoprotein is an ATP-dependent transporter that effluxes many lipophilic anticancer agents out of cells, thereby reducing intracellular drug concentration and results in cancer cell survival. It has been reported that certain kinds of natural compounds and their derivatives inhibit P-glycoprotein function, and overcome the multidrug resistance phenotype.
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DOI:
10.4172/2167-7700.1000156