Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
The success of chemotherapy in cancer treatment is frequently limited by intrinsic or acquired multidrug resistance due to increased expression of a plasma membrane P-glycoprotein . P-glycoprotein is an ATP-dependent transporter that effluxes many lipophilic anticancer agents out of cells, thereby reducing intracellular drug concentration and results in cancer cell survival. It has been reported that certain kinds of natural compounds and their derivatives inhibit P-glycoprotein function, and overcome the multidrug resistance phenotype.