Anesthesia & Clinical Research

Anesthesia & Clinical Research
Open Access

ISSN: 2155-6148

+44 1223 790975

Theoklis Zaoutis

Publications
  • Research Article
    Plasma and Tissue Pharmacokinetics of Cefazolin in an Immature Porcine Model of Pediatric Cardiac Surgery
    Author(s): Todd Kilbaugh, Adam S Himebauch, Theoklis Zaoutis, David Jobes, William Greeley, Susan C Nicolson and Athena F Zuppa Todd Kilbaugh, Adam S Himebauch, Theoklis Zaoutis, David Jobes, William Greeley, Susan C Nicolson and Athena F Zuppa

    Background: Surgical Site Infection (SSI) prevention for children with congenital heart disease is imperative and methods to assess and evaluate the tissue concentrations of prophylactic antibiotics are important to help maximize these efforts. The purpose of this study was to determine the plasma and tissue concentrations of standard-of-care peri-operative cefazolin dosing in an immature porcine model of cardiac surgery and cardiopulmonary bypass. Methods: Piglets (3-5 days old) underwent either median sternotomy (MS) or cardiopulmonary bypass with deep hypothermic circulatory arrest (CPB+DHCA) and received standard of care prophylactic cefazolin for the procedures. Serial plasma and microdialysis sampling of skeletal muscle and subcutaneous tissue adjacent to the surgical site was performed. Cefazolin concentrations were measured, non.. View More»
    DOI: 10.4172/2155-6148.1000508

    Abstract PDF

Relevant Topics

Top