Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Terrence D Ruddy
Canada
Review Article
Cardiac Metabolism Imaging and Chemotherapy Cardiotoxicity
Author(s): Etienne Croteau, Jennifer M Renaud, Chadi Ayoub, Terrence D Ruddy and Robert A deKempEtienne Croteau, Jennifer M Renaud, Chadi Ayoub, Terrence D Ruddy and Robert A deKemp
Cardiac oncology is a field that will become increasingly important in clinical practice as we become more effective in treating cancer and those treated with chemotherapy live longer. Potential cardiac toxicity associated with some chemotherapy treatments can cause significant morbidity. Molecular positron emission tomography (PET) to assess cardiac metabolism is a promising technology that could increase our knowledge of chemotherapy-related toxicity in the heart. We review the utility of PET cardiac imaging to evaluate the toxic effects of chemotherapy on metabolism. Free fatty acids, glucose and ketone bodies are major substrates for cardiac energy consumption, and adaptations to their use can occur under differing conditions. Cardiovascular complications of chemotherapy can include direct effects on metabolism as well as injury to myocardial tissue by effects on endothelial funct.. View More»
DOI:
10.4172/2161-0495.1000213