Cell & Developmental Biology
Open Access

Takehito Sato

Publications

• Research Article
  Impaired Autophagy in Retinal Pigment Epithelial Cells Induced from iPS Cells obtained from a Patient with Sialidosis
  Author(s): Odontuya Davaadorj, Hisako Akatsuka, Yoshiki Yamaguchi, Chisa Okada, Masatoshi Ito, Nahoko Fukunishi, Yoshiki Sekijima, Hideki Ohnota6, Kenji Kawai3, Takahiro Suzuki, Takehito Sato and Yasuyuki SuzukiOdontuya Davaadorj, Hisako Akatsuka, Yoshiki Yamaguchi, Chisa Okada, Masatoshi Ito, Nahoko Fukunishi, Yoshiki Sekijima, Hideki Ohnota6, Kenji Kawai3, Takahiro Suzuki, Takehito Sato and Yasuyuki Suzuki
  
  Sialidosis type I patient-derived induced pluripotent stem cells (iPSCs) were generated from blood mononuclear cells. During embryoid body-like 3D culture, aggregates of patient-derived iPSCs were irregular in shape and had increased vacuoles filled with lipid droplets and cellular components such as damaged mitochondria. Retinal pigment epithelial cells induced from patient-derived iPSCs showed impaired autophagy flux with decreased formation of LC3 puncta. Sialidosis patient-derived iPSCs could provide a useful tool for investigating the mechanism of the autophagy/ lysosome-mediated degradation system. .. View More»
  DOI: 10.4172/2168-9296.1000188

  Abstract PDF

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