Anesthesia & Clinical Research
Open Access

Takayuki Miura

Publications

• Research Article
  Effects of Ischemic and Sevoflurane-induced Preconditioning on Myocardial Infarction and Arrhythmias in Rabbits In Vivo
  Author(s): Takayuki Miura, Uno Imaizumi, Munetaka Furuya, Jun Shirahama, Hirofumi Arisaka and Kazu-ichi Yoshida Takayuki Miura, Uno Imaizumi, Munetaka Furuya, Jun Shirahama, Hirofumi Arisaka and Kazu-ichi Yoshida
  
  Objectives: The present study aimed to investigate whether ischemic or sevoflurane-induced preconditioning exerts infarct size limiting effects and depresses ischemia-reperfusion arrhythmias through opening of mitochondrial KATP channels in rabbits in vivo. Methods: Rabbits anesthetized with ketamine and xylazine given intramuscularly underwent 30 min of left anterior descending coronary artery (LAD) occlusion followed by 3 hrs of reperfusion. Before this, rabbits were randomized into one of five groups. Control rabbits received no intervention before 30 min LAD occlusion and 3 h reperfusion (Group-C). The ischemia-preconditioned (IP) rabbits underwent 5 min LAD occlusion followed by 10 min of reperfusion before prolonged ischemia-reperfusion (Group-IP). In the sevoflurane (S)–preconditioned group, 30 min of sevoflurane exposure at a 1.. View More»
  DOI: 10.4172/2155-6148.1000361

  Abstract PDF

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