Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Sumita Halder
University College of Medical Sciences and GTB Hospital,
New Delhi
India
Research Article
Effect of Chromium on Glutathione-S-Transferase and Catalase Activity and their Respective Gene Expressions in the Brain Tissue of F1 Generation Mice Following Prenatal Exposure: Modulation by Quercetin
Author(s): Sumita Halder, Rajarshi Kar, Swapan K Bhattacharya, Pramod K Mediratta and Basu D BanerjeeSumita Halder, Rajarshi Kar, Swapan K Bhattacharya, Pramod K Mediratta and Basu D Banerjee
Background: The increased use of Cr in several anthropogenic activities and subsequent contamination of water and soil is an increasing concern worldwide. It has also recently drawn attention for its widespread use in dietary supplements.
Objective: In this study we proposed to study whether chromium (Cr) could alter the antioxidant enzymes in brain and their gene expression in the in F1 mice when administered to their dams during gestation and whether quercetin could modulate this effect.
Methods: Animals were administered chromium alone and in combination with quercetin for seven days during their gestation period. Their new born pups (F1 mice) were reared till adulthood. The brain tissue of F1 mice was collected and GST (glutathione-S-transferase) and CAT (catalase) activity was measured and fold increase in the.. View More»
DOI:
10.4172/2161-0495.1000365